Gunslinger Shiloh Coltrane has returned home to work the family's Wyoming ranch, only to find there's still violence ahead. His sister and nephew have been murdered, and the killers are at large. Dr. Sydney Cantrell has come west to start her medical practice, aiming to treat the people of a small town. As she tries to help and heal, she finds disapproval and cruelty the payment in kind. When the two meet, it's an attraction of opposites.
As Shiloh seeks revenge, Sydney seeks to do what's right. Each wants a new life, but will trouble or love find them first?